Suppression of morphine and cocaine self-administration in rats by a mixed mu antagonist kappa agonist (N-CBM-TAMO) and a long-acting selective D-1 antagonist (AS-300)

被引：4

作者：

Archer, S

Glick, SD

Maisonneuve, IM

Bidlack, JM

Xu, JY

Teitler, M

Sebastian, A

ElHamouly, W

Hutchinson, I

机构：

[1] ALBANY MED COLL,DEPT PHARMACOL & NEUROSCI,ALBANY,NY 12208

[2] UNIV ROCHESTER,SCH MED & DENT,DEPT PHYSIOL & PHARMACOL,ROCHESTER,NY 14642

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 10期

关键词：

D O I：

10.1016/0960-894X(96)00186-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-CBM-TAMO 2 was prepared by the same procedure as used for TAMO 1. It was found to be a short-term kappa agonist and along-term mu antagonist. The benzazepine 12, (AS-300) was a potent selective D-1 antagonist. Both compounds suppressed cocaine and morphine self-administration in rats at doses which did not affect water consumption. (C) 1996 Elsevier Science Ltd

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页码：1139 / 1144

页数：6

相关论文

共 19 条

[1] 14-ALPHA,14'BETA-[DITHIOBIS[(2-OXO-2,1-ETHANEDIYL)IMINO]]BIS (7,8-DIHYDROMORPHINONE) AND 14-ALPHA,14'BETA-[DITHIOBIS[(2-OXO-2,1-ETHANEDIYL)IMINO]]BIS[7,8-DIHYDRO-N-(CYCLOPROPYLMETHYL)NORMORPHINONE] - CHEMISTRY AND OPIOID BINDING-PROPERTIES [J].

ARCHER, S ;

SEYEDMOZAFFARI, A ;

JIANG, Q ;

BIDLACK, JM .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (11) :1578-1585

[2] (+/-)-3-ALLYL-7-HALO-8-HYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES AS SELECTIVE HIGH-AFFINITY D1 DOPAMINE RECEPTOR ANTAGONISTS - SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIP [J].

BAINDUR, N ;

TRAN, M ;

NIZNIK, HB ;

GUAN, HC ;

SEEMAN, P ;

NEUMEYER, JL .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) :67-72

[3] SYNTHESIS AND RECEPTOR AFFINITIES OF SOME CONFORMATIONALLY RESTRICTED ANALOGS OF THE DOPAMINE D1 SELECTIVE LIGAND (5R)-8-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL [J].

BERGER, JG ;

CHANG, WK ;

CLADER, JW ;

HOU, D ;

CHIPKIN, RE ;

MCPHAIL, AT .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1913-1921

[4]

Bergman J., 1990, Behav Pharmacol, V1, P355

[5]

CAINE SB, 1995, BRAIN RES, V692, P47

[6] (+/-)-7-CHLORO-8-HYDROXY-1-(4'-[I-125]IODOPHENYL)-3-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE - A POTENTIAL CNS D-1 DOPAMINE RECEPTOR IMAGING AGENT [J].

CHUMPRADIT, S ;

KUNG, HF ;

BILLINGS, J ;

KUNG, MP ;

PAN, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (07) :1431-1435

[7] IRREVERSIBLE INTERACTION OF BETA-HALOALKYLAMINE DERIVATIVES WITH DOPAMINE-D1 AND DOPAMINE-D2 RECEPTORS [J].

CROSS, AJ ;

WADDINGTON, JL ;

ROSS, ST .

LIFE SCIENCES, 1983, 32 (24) :2733-2740

[8] MECHANISMS OF ACTION OF IBOGAINE AND HARMALINE CONGENERS BASED ON RADIOLIGAND BINDING-STUDIES [J].

DEECHER, DC ;

TEITLER, M ;

SODERLUND, DM ;

BORNMANN, WG ;

KUEHNE, ME ;

GLICK, SD .

BRAIN RESEARCH, 1992, 571 (02) :242-247

[9]

DICHIARA G, 1988, J PHARMACOL EXP THER, V244, P1067

[10] LACK OF EVIDENCE FOR AN INVOLVEMENT OF NUCLEUS-ACCUMBENS DOPAMINE D-1 RECEPTORS IN THE INITIATION OF HEROIN SELF-ADMINISTRATION IN THE RAT [J].

GERRITS, MAFM ;

RAMSEY, NF ;

WOLTERINK, G ;

VANREE, JM .

PSYCHOPHARMACOLOGY, 1994, 114 (03) :486-494