Cell Immortality and Hallmarks of Cancer

被引：24

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] New York Med Coll, Brander Canc Res Inst, 19 Bradhurst Ave,Suite 2400, Hawthorne, NY 10532 USA

来源：

CELL CYCLE | 2003年 / 2卷 / 04期

关键词：

cancer; immortalization; metastasis; growth arrest; mutations; telomerase; selection;

D O I：

10.4161/cc.2.4.470

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In growth-limiting conditions, cells that express telomerase and inactivate tumor suppressors have a selective advantage due to resistance to growth arrest. Accidentally such cells become immortal.

引用

页码：296 / 299

页数：4

共 32 条

[1] Constitutive telomerase expression promotes mammary carcinomas in aging mice [J].

Artandi, SE ;

Alson, S ;

Tietze, MK ;

Sharpless, NE ;

Ye, S ;

Greenberg, RA ;

Castrillon, DH ;

Horner, JW ;

Weiler, SR ;

Carrasco, RD ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8191-8196

[2] Metastasis genes: A progression puzzle [J].

Bernards, R ;

Weinberg, RA .

NATURE, 2002, 418 (6900) :823-823

[3] Stress-induced mutagenesis in bacteria [J].

Bjedov, I ;

Tenaillon, O ;

Gérard, B ;

Souza, V ;

Denamur, E ;

Radman, M ;

Taddei, F ;

Matic, I .

SCIENCE, 2003, 300 (5624) :1404-1409

[4] Cell senescence and hypermitogenic arrest [J].

Blagosklonny, MV .

EMBO REPORTS, 2003, 4 (04) :358-362

[5] Oncogenic resistance to growth-limiting conditions [J].

Blagosklonny, MV .

NATURE REVIEWS CANCER, 2002, 2 (03) :221-225

[6] Genetic instability and darwinian selection in tumours (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999) [J].

Cahill, DP ;

Kinzler, KW ;

Vogelstein, B ;

Lengauer, C .

TRENDS IN CELL BIOLOGY, 1999, 9 (12) :M57-M60

[7] Dissemination and growth of cancer cells in metastatic sites [J].

Chambers, AF ;

Groom, AC ;

MacDonald, IC .

NATURE REVIEWS CANCER, 2002, 2 (08) :563-572

[8] Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression [J].

Chang, S ;

Khoo, CM ;

Naylor, ML ;

Maser, RS ;

DePinho, RA .

GENES & DEVELOPMENT, 2003, 17 (01) :88-100

[9] Telomerase extracurricular activities [J].

Chang, S ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12520-12522

[10] Possible role of telomerase activation in the cancer predisposition of patients with hereditary nonpolyposis colorectal cancers [J].

Cheng, AJ ;

Tang, RP ;

Wang, JY ;

See, LC ;

Wang, TCV .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (04) :316-321

← 1 2 3 4 →