Cell Immortality and Hallmarks of Cancer

被引：25

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] New York Med Coll, Brander Canc Res Inst, 19 Bradhurst Ave,Suite 2400, Hawthorne, NY 10532 USA

来源：

CELL CYCLE | 2003年 / 2卷 / 04期

关键词：

cancer; immortalization; metastasis; growth arrest; mutations; telomerase; selection;

D O I：

10.4161/cc.2.4.470

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In growth-limiting conditions, cells that express telomerase and inactivate tumor suppressors have a selective advantage due to resistance to growth arrest. Accidentally such cells become immortal.

引用

页码：296 / 299

页数：4