Syntheses of substituted pyridines, quinolines and diazines via palladium-catalyzed cross-coupling of aryl Grignard reagents

被引：79

作者：

Bonnet, V

Mongin, F

Trécourt, F

Quéguiner, G

Knochel, P

机构：

[1] IRCOF, Lab Chim Organ Fine & Heterocycl, UMR 6014, F-76131 Mont St Aignan, France

[2] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

TETRAHEDRON | 2002年 / 58卷 / 22期

关键词：

palladium catalysis; Grignard reagents; coupling reactions; azines;

D O I：

10.1016/S0040-4020(02)00411-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed cross-coupling reactions between arylmagnesium halides (phenylmagnesium chloride, mesitylmagnesium bromide, 4-(methoxycarbonyl)phenylmagnesium chloride and 4-cyanophenylmagnesium chloride) and halopyridines allowed the synthesis of substituted pyridines. Owing to the remarkably mild conditions used (often below 0degreesC), the reaction could be extended to the use of functionalized halopyridines, haloquinolines and halodiazines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4429 / 4438

页数：10

共 64 条

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