RNA regulation: a new genetics?

被引：556

作者：

Mattick, JS ^{[1
]}

机构：

[1] Univ Queensland, ARC Special Res Ctr Funct & Appl Genom, Brisbane, Qld 4072, Australia

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrg1321

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Do non-coding RNAs that are derived from the introns and exons of protein-coding and non-protein-coding genes represent a fundamental advance in the genetic operating system of higher organisms? Recent evidence from comparative genomics and molecular genetics indicates that this might be the case. If so, there will be profound consequences for our understanding of the genetics of these organisms, and in particular how the trajectories of differentiation and development and the differences among individuals and species are genomically programmed. But how might this hypothesis be tested?

引用

页码：316 / 323

页数：8

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