A practical method for the preparation of alpha'-chloroketones of N-carbamate protected-alpha-aminoacids

被引：49

作者：

Chen, P

Cheng, PTW

Spergel, SH

Zahler, R

Wang, XB

Thottathil, J

Barrish, JC

Polniaszek, RP

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DISCOVERY CHEM,PRINCETON,NJ 08543

[2] CHEM PROC RES,NEW BRUNSWICK,NJ 08903

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00605-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical method for the preparation of alpha-N-BOC-epoxides from protected amino acid esters based on the Kowalski homologation reaction is described This procedure can be readily performed on a large scale without the use of hazardous reagents and has allowed preparation of epoxides 3 in multi-kilogram quantities. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：3175 / 3178

页数：4

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