Myeloid hematopoietic growth factors and their role in prevention and/or treatment of neonatal sepsis

被引:11
作者
Parravicini, E
de Ven, C
Anderson, L
Cairo, MS
机构
[1] Columbia Univ, Dept Pediat, Div Pediat Oncol, New York, NY 10027 USA
[2] Columbia Univ, Dept Pediat, Dept Neonatol, New York, NY 10027 USA
关键词
D O I
10.1053/tmrv.2002.29348
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sepsis continues to be an important cause of morbidity and mortality among both full-term and preterm infants, secondary to an immaturity in neonatal host defense. The incidence of neonatal sepsis ranges from 30% in very low birth weight infants to 0.4% in preterm neonates and 0.1% in term neonates. The dysregulation of the expression and production of hematopoietic cytokines in the neonate contributes to quantitative and qualitative deficiencies in neonatal myeloid progenitor activity and decreased availability and function of mature effector neutrophils. These abnormalities contribute in large part to. the increased incidence and mortality associated with neonatal sepsis. In this review, we have summarized and analyzed the studies investigating the dysregulation, expression and production of myelopoietic growth factors in neonates, the preclinical in vivo effects of myelopoietic growth factors in neonatal animals, the preclinical in vivo effects of myelopoietic growth factors during experimental sepsis in neonatal animals, the in vitro effects of growth factors on human neonatal phagocytic immunity, and clinical results of myelopoietic growth factors in human neonates. Future studies should be focused on investigating other abnormalities of neonatal host defense and multiple and simultaneous approaches to circumvent identified defects to attempt to reduce both the incidence and severity of neonatal host defense. Copyright (C) 2002 by W.B. Saunders Company.
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页码:11 / 24
页数:14
相关论文
共 68 条
[21]   DECREASED STIMULATED GM-CSF PRODUCTION AND GM-CSF GENE-EXPRESSION BUT NORMAL NUMBERS OF GM-CSF RECEPTORS IN HUMAN TERM NEWBORNS COMPARED WITH ADULTS [J].
CAIRO, MS ;
SUEN, Y ;
KNOPPEL, E ;
VANDEVEN, C ;
NGUYEN, A ;
SENDER, L .
PEDIATRIC RESEARCH, 1991, 30 (04) :362-367
[22]   RESULTS OF A PHASE I/II TRIAL OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN VERY-LOW-BIRTH-WEIGHT NEONATES - SIGNIFICANT INDUCTION OF CIRCULATORY NEUTROPHILS, MONOCYTES, PLATELETS, AND BONE-MARROW NEUTROPHILS [J].
CAIRO, MS ;
CHRISTENSEN, R ;
SENDER, LS ;
ELLIS, R ;
ROSENTHAL, J ;
VANDEVEN, C ;
WORCESTER, C ;
AGOSTI, JM .
BLOOD, 1995, 86 (07) :2509-2515
[23]   RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PRIMES NEONATAL GRANULOCYTES FOR ENHANCED OXIDATIVE-METABOLISM AND CHEMOTAXIS [J].
CAIRO, MS ;
VANDEVEN, C ;
TOY, C ;
MAUSS, D ;
SENDER, L .
PEDIATRIC RESEARCH, 1989, 26 (05) :395-399
[24]  
CAIRO MS, 1994, EXP HEMATOL, V22, P1118
[25]  
CAIRO MS, 1991, BIOL NEONATE, V59, P13
[26]   DECREASED G-CSF AND IL-3 PRODUCTION AND GENE-EXPRESSION FROM MONONUCLEAR-CELLS OF NEWBORN-INFANTS [J].
CAIRO, MS ;
YU, S ;
KNOPPEL, E ;
DANA, R ;
PARK, L ;
CLARK, S ;
VANDEVEN, C ;
SENDER, L .
PEDIATRIC RESEARCH, 1992, 31 (06) :574-578
[27]  
CAIRO MS, 1990, BLOOD, V76, P1788
[28]  
CAIRO MS, 1990, REV INF DIS S, V12, P492
[29]   MAST-CELL GROWTH-FACTOR (C-KIT LIGAND) SUPPORTS THE GROWTH OF HUMAN MULTIPOTENTIAL PROGENITOR CELLS WITH A HIGH REPLATING POTENTIAL [J].
CAROW, CE ;
HANGOC, G ;
COOPER, SH ;
WILLIAMS, DE ;
BROXMEYER, HE .
BLOOD, 1991, 78 (09) :2216-2221
[30]   TRANSFORMING GROWTH-FACTOR-BETA-1, MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA, AND INTERLEUKIN-8 GENE-EXPRESSION IS LOWER IN STIMULATED HUMAN NEONATAL COMPARED WITH ADULT MONONUCLEAR-CELLS [J].
CHANG, M ;
SUEN, Y ;
LEE, SM ;
BALY, D ;
BUZBY, JS ;
KNOPPEL, E ;
WOLPE, S ;
CAIRO, MS .
BLOOD, 1994, 84 (01) :118-124