New insights into the mechanism of action of acetaminophen:: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

被引:152
作者
Aronoff, DM
Oates, JA
Boutaud, O [1 ]
机构
[1] Vanderbilt Univ, Dept Pharmacol, Div Clin Pharmacol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Dept Internal Med, Div Clin Pharmacol, Nashville, TN 37232 USA
[3] Univ Michigan, Hlth Syst, Div Infect Dis, Dept Internal Med, Ann Arbor, MI 48109 USA
关键词
D O I
10.1016/j.clpt.2005.09.009
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:9 / 19
页数:11
相关论文
共 66 条
[1]  
[Anonymous], 1893, THER MONATSCH
[2]   Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes [J].
Aronoff, DM ;
Boutaud, O ;
Marnett, LJ ;
Oates, JA .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 304 (02) :589-595
[3]   Antipyretics: Mechanisms of action and clinical use in fever suppression [J].
Aronoff, DM ;
Neilson, EG .
AMERICAN JOURNAL OF MEDICINE, 2001, 111 (04) :304-315
[4]   INHIBITION OF PROSTAGLANDIN SYNTHETASES DERIVED FROM NEURONAL AND GLIAL-CELLS AND RAT RENAL MEDULLA BY ORTHO-SUBSTITUTED, META-SUBSTITUTED AND PARA-SUBSTITUTED AMINOPHENOLIC COMPOUNDS [J].
BAUMANN, J ;
VANBRUCHHAUSEN, F ;
WURM, G .
PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, 1983, 10 (03) :319-329
[5]   Mechanism of action of acetaminophen: Is there a cyclooxygenase 3? [J].
Botting, RM .
CLINICAL INFECTIOUS DISEASES, 2000, 31 :S202-S210
[6]   Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases [J].
Boutaud, O ;
Aronoff, DM ;
Richardson, JH ;
Marnett, LJ ;
Oates, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (10) :7130-7135
[7]   Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway [J].
Boutaud, O ;
Brame, CJ ;
Salomon, RG ;
Roberts, LJ ;
Oates, JA .
BIOCHEMISTRY, 1999, 38 (29) :9389-9396
[8]  
BOYD JA, 1981, J PHARMACOL EXP THER, V219, P659
[9]  
BRODIE BB, 1949, J PHARMACOL EXP THER, V97, P58
[10]   Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation [J].
Calzada, C ;
Vericel, E ;
Lagarde, M .
BIOCHEMICAL JOURNAL, 1997, 325 :495-500