New insights into the mechanism of action of acetaminophen:: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

被引：152

作者：

Aronoff, DM

Oates, JA

Boutaud, O ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Pharmacol, Div Clin Pharmacol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Internal Med, Div Clin Pharmacol, Nashville, TN 37232 USA

[3] Univ Michigan, Hlth Syst, Div Infect Dis, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2006年 / 79卷 / 01期

关键词：

D O I：

10.1016/j.clpt.2005.09.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：9 / 19

页数：11

共 66 条

[11] Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: A possible site of prostaglandin synthesis responsible for fever [J].

Cao, CY ;

Matsumura, K ;

Yamagata, K ;

Watanabe, Y .

BRAIN RESEARCH, 1996, 733 (02) :263-272

[12]

CARPENTER HM, 1981, J PHARMACOL EXP THER, V218, P161

[13] Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. [J].

Catella-Lawson, F ;

Reilly, MP ;

Kapoor, SC ;

Cucchiara, AJ ;

DeMarco, S ;

Tournier, B ;

Vyas, SN ;

FitzGerald, GA .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (25) :1809-1817

[14] COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression [J].

Chandrasekharan, NV ;

Dai, H ;

Roos, KLT ;

Evanson, NK ;

Tomsik, J ;

Elton, TS ;

Simmons, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13926-13931

[15] PARACETAMOL AND PHENACETIN [J].

CLISSOLD, SP .

DRUGS, 1986, 32 :46-59

[16] EFFECT OF SUBSTRATE CONCENTRATION ON INHIBITION OF PROSTAGLANDIN SYNTHETASE OF BULL SEMINAL-VESICLES BY ANTI-INFLAMMATORY DRUGS AND FENAMIC ACID ANALOGS [J].

CUSHMAN, DW ;

CHEUNG, HS .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 424 (03) :449-459

[17]

Davies NM, 2004, J PHARM PHARM SCI, V7, P217

[18] HIGHER OXIDATION-STATES OF PROSTAGLANDIN-H SYNTHASE - RAPID ELECTRONIC SPECTROSCOPY DETECTED 2 SPECTRAL INTERMEDIATES DURING THE PEROXIDASE REACTION WITH PROSTAGLANDIN-G2 [J].

DIETZ, R ;

NASTAINCZYK, W ;

RUF, HH .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 171 (1-2) :321-328

[19] COX-3: in the wrong frame in mind [J].

Dinchuk, JE ;

Liu, RQ ;

Trzaskos, JM .

IMMUNOLOGY LETTERS, 2003, 86 (01) :121-121

[20] Cyclooxygenase in biology and disease [J].

Dubois, RN ;

Abramson, SB ;

Crofford, L ;

Gupta, RA ;

Simon, LS ;

Van De Putte, LBA ;

Lipsky, PE .

FASEB JOURNAL, 1998, 12 (12) :1063-1073

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