Measurement of gastric emptying in man using deuterated octanoic acid

被引:22
作者
Bluck, LJC
Harding, M
French, S
Wright, A
Halliday, D
Coward, WA
机构
[1] MRC Human Nutr Res, Elsie Widdowson Lab, Cambridge CB1 9NL, England
[2] No Gen Hosp, Ctr Human Nutr, Sheffield S5 7AU, S Yorkshire, England
[3] Univ Sheffield, Sheffield S5 7AU, S Yorkshire, England
[4] Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England
关键词
D O I
10.1002/rcm.541
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Gamma scintigraphy is considered the gold standard for the measurement of gastric emptying in humans. Recently, it has been proposed that a [C-13]octanoate breath test can be used as an alternative technique for measuring gastric emptying of the solid phase, but the results from the two methods are not directly equivalent since in the breath test the label is subject to post-absorptive processing and consequently the emptying functions cannot be observed directly. This work investigates an alternative stable isotope method using deuterated octanoate where the kinetics of redistribution between and elimination from the various body pools are much more easily modelled. Gastric emptying was studied in healthy human volunteers by simultaneous measurement using both [C-13]octanoate and [H-2]octanoate as well as gamma scintigraphy. Comparison of the gastric emptying functions from the deuterium method and scintigraphy indicated that the two methods gave equivalent results. The new method can therefore be used in populations considered too vulnerable to ionising radiation to allow gamma scintigraphy to be performed, or as a proxy gold standard in laboratories where scintigraphic methods are unavailable, allowing further comparisons with the breath test method to be made to validate the latter in different population groups. Copyright (C) 2001 John Wiley Sons, Ltd.
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收藏
页码:127 / 133
页数:7
相关论文
共 20 条
[1]   [C-13]octanoic acid breath test for gastric emptying of solids: Accuracy, reproducibility, and comparison with scintigraphy [J].
Choi, MG ;
Camilleri, M ;
Burton, DD ;
Zinsmeister, AR ;
Forstrom, LA ;
Nair, KS .
GASTROENTEROLOGY, 1997, 112 (04) :1155-1162
[2]   13C octanoic acid breath test:: Valueless test for gastric emptying?: Reply [J].
Choi, MG ;
Camilleri, M ;
Zinsmeister, AR .
GASTROENTEROLOGY, 1998, 114 (04) :858-859
[3]   GASTRIC-EMPTYING IN NORMAL SUBJECTS - A REPRODUCIBLE TECHNIQUE USING A SINGLE SCINTILLATION CAMERA AND COMPUTER-SYSTEM [J].
COLLINS, PJ ;
HOROWITZ, M ;
COOK, DJ ;
HARDING, PE ;
SHEARMAN, DJC .
GUT, 1983, 24 (12) :1117-1125
[4]  
ELASHOFF JD, 1982, GASTROENTEROLOGY, V83, P1306
[5]   Digestibility of cooked and raw egg protein in humans as assessed by stable isotope techniques [J].
Evenepoel, P ;
Geypens, B ;
Luypaerts, A ;
Hiele, M ;
Ghoos, Y ;
Rutgeerts, P .
JOURNAL OF NUTRITION, 1998, 128 (10) :1716-1722
[6]   MEASUREMENT OF GASTRIC-EMPTYING RATE OF SOLIDS BY MEANS OF A CARBON-LABELED OCTANOIC-ACID BREATH TEST [J].
GHOOS, YF ;
MAES, BD ;
GEYPENS, BJ ;
MYS, G ;
HIELE, MI ;
RUTGEERTS, PJ ;
VANTRAPPEN, G .
GASTROENTEROLOGY, 1993, 104 (06) :1640-1647
[7]   A valid, accurate, office based non-radioactive test for gastric emptying of solids [J].
Lee, JS ;
Camilleri, M ;
Zinsmeister, AR ;
Burton, DD ;
Kost, LJ ;
Klein, PD .
GUT, 2000, 46 (06) :768-773
[8]   KINETICS OF (CO2)-C-13 ELIMINATION AFTER INGESTION OF C-13 BICARBONATE - THE EFFECTS OF EXERCISE AND ACID-BASE-BALANCE [J].
LEESE, GP ;
NICOLL, AE ;
VARNIER, M ;
THOMPSON, J ;
SCRIMGEOUR, CM ;
RENNIE, MJ .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1994, 24 (12) :818-823
[9]   [ASTERISK-C]OCTANOIC ACID BREATH TEST TO MEASURE GASTRIC-EMPTYING RATE OF SOLIDS [J].
MAES, BD ;
GHOOS, YF ;
RUTGEERTS, PJ ;
HIELE, MI ;
GEYPENS, B ;
VANTRAPPEN, G .
DIGESTIVE DISEASES AND SCIENCES, 1994, 39 (12) :S104-S106
[10]   13C-octanoic acid breath test for gastric emptying rate of solids [J].
Maes, BD ;
Geypens, BJ ;
Ghoos, YF ;
Hiele, MI ;
Rutgeerts, RJ .
GASTROENTEROLOGY, 1998, 114 (04) :856-857