Substituted 2-(cyanomethyl-amino)-acetamides by a novel three-component reaction

被引：18

作者：

Behnke, D

Taube, R

Illgen, K

Nerdinger, S

Herdtweck, E

机构：

[1] Morphochem AG, D-81379 Munich, Germany

[2] Tech Univ Munich, Inst Anorgan Chem, D-85747 Garching, Germany

来源：

SYNLETT | 2004年 / 04期

关键词：

multi-component condensation; MCRs; Ugi reaction; isocyanides; aliphatic nitriles;

D O I：

10.1055/s-2004-817764

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel three-component, one-pot reaction between primary (S)-amino acid amides, aldehydes and isocyanides in the presence of acetic acid yielding substituted 2-(cyanomethl-amino)-acetamides 4 in good yields, is described. First efforts to investigate the mechanism of this reaction were undertaken.

引用

页码：688 / 692

页数：5

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