Substituted 2-(cyanomethyl-amino)-acetamides by a novel three-component reaction

被引:18
作者
Behnke, D
Taube, R
Illgen, K
Nerdinger, S
Herdtweck, E
机构
[1] Morphochem AG, D-81379 Munich, Germany
[2] Tech Univ Munich, Inst Anorgan Chem, D-85747 Garching, Germany
关键词
multi-component condensation; MCRs; Ugi reaction; isocyanides; aliphatic nitriles;
D O I
10.1055/s-2004-817764
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel three-component, one-pot reaction between primary (S)-amino acid amides, aldehydes and isocyanides in the presence of acetic acid yielding substituted 2-(cyanomethl-amino)-acetamides 4 in good yields, is described. First efforts to investigate the mechanism of this reaction were undertaken.
引用
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页码:688 / 692
页数:5
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