Chemokines and chemokine receptors: an overview

被引：196

作者：

Bonecchi, Raffaella ^{[1
,2
]}

Galliera, Emanuela ^{[2
]}

Borroni, Elena M. ^{[1
,2
]}

Corsi, Massimiliano M. ^{[2
]}

Locati, Massimo ^{[1
,2
]}

Mantovani, Alberto ^{[1
,2
]}

机构：

[1] Ist Clin Humanitas, IRCCS, I-20089 Rozzano, Italy

[2] Univ Milan, Fac Med, Inst Gen Pathol, I-20133 Milan, Italy

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Chemokine; Chemokine Receptor; Inflammation; Review; CUTTING EDGE; CC-CHEMOKINE; IMMUNE-RESPONSE; CXC CHEMOKINES; D6; INFLAMMATION; EXPRESSION; DECOY; SYSTEM; CANCER;

D O I：

10.2741/3261

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.

引用

页码：540 / 551

页数：12

共 57 条

[41] The β-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors
Nibbs, RJB
Kriehuber, E
Ponath, PD
Parent, D
Qin, SX
Campbell, JDM
Henderson, A
Kerjaschki, D
Maurer, D
Graham, GJ
Rot, A
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (03) : 867 - 877
[42] The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS
O'Brien, SJ
Moore, JP
[J]. IMMUNOLOGICAL REVIEWS, 2000, 177 : 99 - 111
[43] Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: Induction of the B cell-activating chemokine, CXC chemokine ligand 13
Perrier, P
Martinez, FO
Locati, M
Bianchi, G
Nebuloni, M
Vago, G
Bazzoni, F
Sozzani, S
Allavena, P
Mantovani, A
[J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (11) : 7031 - 7042
[44] CXC chemokines: the regulatory link between inflammation and angiogenesis
Romagnani, P
Lasagni, L
Annunziato, F
Serio, M
Romagnani, S
[J]. TRENDS IN IMMUNOLOGY, 2004, 25 (04) : 201 - 209
[45] The biology of chemokines and their receptors
Rossi, D
Zlotnik, A
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 : 217 - 243
[46] Contribution of Duffy antigen to chemokine function
Rot, A
[J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (06) : 687 - 694
[47] Chemoattractants and their receptors in homeostasis and inflammation
Sallusto, F
Mackay, CR
[J]. CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (06) : 724 - 731
[48] Life and death in the granuloma: immunopathology of tuberculosis
Saunders, Bernadette M.
Britton, Warwick J.
[J]. IMMUNOLOGY AND CELL BIOLOGY, 2007, 85 (02) : 103 - 111
[49] Sozzani S, 1998, J IMMUNOL, V161, P1083
[50] CXC chemokines in angiogenesis
Strieter, RM
Burdick, MD
Gomperts, BN
Belperio, JA
Keane, MP
[J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (06) : 593 - 609

← 1 2 3 4 5 6 →