Causes, consequences, and reversal of immune system aging

被引：541

作者：

Montecino-Rodriguez, Encarnacion ^{[1
]}

Berent-Maoz, Beata ^{[1
]}

Dorshkind, Kenneth ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 03期

关键词：

HEMATOPOIETIC STEM-CELLS; AGE-RELATED-CHANGES; BONE-MARROW; B-CELL; GROWTH-HORMONE; SELF-RENEWAL; LYMPHOCYTE DEVELOPMENT; ELDERLY INDIVIDUALS; CALORIC RESTRICTION; SIGNALING PATHWAYS;

D O I：

10.1172/JCI64096

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues. As a result, elderly individuals do not respond to immune challenge as robustly as the young. An important goal of aging research is to define the cellular changes that occur in the immune system and the molecular events that underlie them. Considerable progress has been made in this regard, and this information has provided the rationale for clinical trials to rejuvenate the aging immune system.

引用

页码：958 / 965

页数：8

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