The double life of a B-1 cell: self-reactivity selects for protective effector functions

被引:699
作者
Baumgarth, Nicole [1 ]
机构
[1] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA
基金
美国国家卫生研究院;
关键词
NATURAL ANTIBODY-PRODUCTION; TOLL-LIKE RECEPTORS; REGULATORY B-CELLS; MARGINAL-ZONE; IMMUNOGLOBULIN-M; INFLUENZA-VIRUS; PERITONEAL-CAVITY; CUTTING EDGE; B1B CELLS; T-CELLS;
D O I
10.1038/nri2901
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.
引用
收藏
页码:34 / 46
页数:13
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