The double life of a B-1 cell: self-reactivity selects for protective effector functions

被引：699

作者：

Baumgarth, Nicole ^{[1
]}

机构：

[1] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

NATURAL ANTIBODY-PRODUCTION; TOLL-LIKE RECEPTORS; REGULATORY B-CELLS; MARGINAL-ZONE; IMMUNOGLOBULIN-M; INFLUENZA-VIRUS; PERITONEAL-CAVITY; CUTTING EDGE; B1B CELLS; T-CELLS;

D O I：

10.1038/nri2901

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.

引用

页码：34 / 46

页数：13

共 151 条

[21]

Boes M, 1998, J IMMUNOL, V160, P4776

[22] SERUM IMMUNOGLOBULIN LEVELS AND NATURALLY-OCCURRING ANTIBODIES AGAINST CARBOHYDRATE ANTIGENS IN GERM-FREE BALB/C MICE FED CHEMICALLY DEFINED ULTRAFILTERED DIET [J].

BOS, NA ;

KIMURA, H ;

MEEUWSEN, CG ;

DEVISSER, H ;

HAZENBERG, MP ;

WOSTMANN, BS ;

PLEASANTS, JR ;

BENNER, R ;

MARCUS, DM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (12) :2335-2339

[23] Regulatory B cells as inhibitors of immune responses and inflammation [J].

Bouaziz, Jean-David ;

Yanaba, Koichi ;

Tedder, Thomas F. .

IMMUNOLOGICAL REVIEWS, 2008, 224 :201-214

[24] Characterization of cells of the B lineage in the human adult greater omentum [J].

Boursier, Laurent ;

Montalto, Stephen Attard ;

Raju, Shanti ;

Culora, Giuseppe ;

Spencer, Jo .

IMMUNOLOGY, 2006, 119 (01) :90-97

[25]

Bouvet JP, 1998, INFECT IMMUN, V66, P1

[26] Impairment of the antipolysaccharide response in splenectomized patients is due to the lack of immunoglobulin M memory B cells [J].

Carsetti, R ;

Pantosti, A ;

Quinti, I .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (08) :1189-1190

[27] Peripheral development of B cells in mouse and man [J].

Carsetti, R ;

Rosado, MM ;

Wardemann, H .

IMMUNOLOGICAL REVIEWS, 2004, 197 :179-191

[28] HUMAN-LYMPHOCYTES MAKING RHEUMATOID-FACTOR AND ANTIBODY TO SSDNA BELONG TO LEU-1+ B-CELL SUBSET [J].

CASALI, P ;

BURASTERO, SE ;

NAKAMURA, M ;

INGHIRAMI, G ;

NOTKINS, AL .

SCIENCE, 1987, 236 (4797) :77-81

[29] B cell receptor signal strength determines B cell fate [J].

Casola, S ;

Otipoby, KL ;

Alimzhanov, M ;

Humme, S ;

Uyttersprot, N ;

Kutok, JL ;

Carroll, MC ;

Rajewsky, K .

NATURE IMMUNOLOGY, 2004, 5 (03) :317-327

[30] IgM Antibodies to Apoptosis-Associated Determinants Recruit C1q and Enhance Dendritic Cell Phagocytosis of Apoptotic Cells [J].

Chen, Yifang ;

Park, Yong-Beom ;

Patel, Ekta ;

Silverman, Gregg J. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (10) :6031-6043

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