The double life of a B-1 cell: self-reactivity selects for protective effector functions

被引：699

作者：

Baumgarth, Nicole ^{[1
]}

机构：

[1] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

NATURAL ANTIBODY-PRODUCTION; TOLL-LIKE RECEPTORS; REGULATORY B-CELLS; MARGINAL-ZONE; IMMUNOGLOBULIN-M; INFLUENZA-VIRUS; PERITONEAL-CAVITY; CUTTING EDGE; B1B CELLS; T-CELLS;

D O I：

10.1038/nri2901

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.

引用

页码：34 / 46

页数：13

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