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Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8+ T Cells
被引:91
作者:
Hufford, Matthew M.
[1
,2
]
Richardson, Graham
[2
,3
]
Zhou, Haixia
[1
]
Manicassamy, Balaji
[4
,5
]
Garcia-Sastre, Adolfo
[4
,5
,6
]
Enelow, Richard I.
[7
,8
]
Braciale, Thomas J.
[1
,2
,9
]
机构:
[1] Univ Virginia, Beirne B Carter Ctr Immunol Res, Charlottesville, VA 22903 USA
[2] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA
[3] Univ Virginia, Ctr Cell Signaling, Charlottesville, VA USA
[4] Mt Sinai Sch Med, Dept Microbiol, New York, NY USA
[5] Mt Sinai Sch Med, Global Hlth & Emerging Pathogens Inst, New York, NY USA
[6] Mt Sinai Sch Med, Div Infect Dis, Dept Med, New York, NY USA
[7] Dartmouth Med Sch, Dept Microbiol Immunol, Lebanon, NH USA
[8] Dartmouth Med Sch, Dept Med, Lebanon, NH USA
[9] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA
来源:
PLOS ONE
|
2012年
/
7卷
/
10期
基金:
美国国家卫生研究院;
关键词:
TUMOR-NECROSIS-FACTOR;
VIRUS INFECTION;
DENDRITIC CELLS;
POLYMORPHONUCLEAR LEUKOCYTES;
IN-VIVO;
A VIRUS;
ACTIVATION;
RESPONSES;
MICE;
IMMUNOPATHOLOGY;
D O I:
10.1371/journal.pone.0046581
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Influenza A virus (IAV) is a leading cause of respiratory tract disease worldwide. Anti-viral CD8(+) T lymphocytes responding to IAV infection are believed to eliminate virally infected cells by direct cytolysis but may also contribute to pulmonary inflammation and tissue damage via the release of pro-inflammatory mediators following recognition of viral antigen displaying cells. We have previously demonstrated that IAV antigen expressing inflammatory cells of hematopoietic origin within the infected lung interstitium serve as antigen presenting cells (APC) for infiltrating effector CD8(+) T lymphocytes; however, the spectrum of inflammatory cell types capable of serving as APC was not determined. Here, we demonstrate that viral antigen displaying neutrophils infiltrating the IAV infected lungs are an important cell type capable of acting as APC for effector CD8(+) T lymphocytes in the infected lungs and that neutrophils expressing viral antigen as a result of direct infection by IAV exhibit the most potent APC activity. Our findings suggest that in addition to their suggested role in induction of the innate immune responses to IAV, virus clearance, and the development of pulmonary injury, neutrophils can serve as APCs to anti-viral effector CD8(+) T cells within the infected lung interstitium.
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