Confounding and effect modification:: possible explanation for variation in the results on the association between oral and systemic diseases

被引：32

作者：

Ylöstalo, PV

Knuuttila, ML

机构：

[1] Univ Oulu, Inst Dent, Dept Periodontol & Geriatr Dent, Oulu 90014, Finland

[2] Oulu Univ Hosp, Oral & Maxillofacial Dept, Oulu, Finland

来源：

JOURNAL OF CLINICAL PERIODONTOLOGY | 2006年 / 33卷 / 02期

关键词：

cardiovascular diseases; confounding; effect modification; oral diseases;

D O I：

10.1111/j.1600-051X.2005.00886.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objectives: There is large variation in the results of studies on the association between periodontitis and systemic diseases. The variation might be explained by the fact that the association between periodontitis and systemic diseases is confounded, or the association might be modified by extraneous factors. In this article, we show, using simple examples, how confounding and effect modification may cause variation in results. In addition, these examples show that uncontrolled or partially controlled confounders can induce spurious associations. Conclusion: Confounding and effect modification may explain the variation in the results of studies on the association between periodontitis and systemic diseases.

引用

页码：104 / 108

页数：5

共 15 条

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