New routes to conformationally restricted peptide building blocks: A convenient preparation of bicyclic piperazinone derivatives

被引：29

作者：

Fobian, YM ^{[1
]}

dAvignon, DA ^{[1
]}

Moeller, KD ^{[1
]}

机构：

[1] WASHINGTON UNIV,DEPT CHEM,ST LOUIS,MO 63130

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 03期

关键词：

D O I：

10.1016/0960-894X(96)00019-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A facile route for the synthesis of peptide building blocks that constrain the peptide backbone with a 1,4-diazabicyclo[4.3.0]nonane ring skeleton is reported. The synthesis employed an anodic amide oxidation based approach for generating a functionalized proline derivative, and then utilized the derivative as a general substrate for rapidly assembling the bicyclic ring system.

引用

页码：315 / 318

页数：4

共 39 条

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