The Adipocyte as an Endocrine Cell

被引：314

作者：

Halberg, Nils ^{[1
,2
]}

Wernstedt-Asterholm, Ingrid ^{[1
]}

Scherer, Philipp E. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA

[2] Univ Copenhagen, Dept Biomed Sci, DK-2200 Copenhagen N, Denmark

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2008年 / 37卷 / 03期

关键词：

D O I：

10.1016/j.ecl.2008.07.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue contains many cell types. Among the more abundant are adipocytes, preadipocytes, immune cells, and endothelial cells. During times of excess caloric intake, these cells have to adjust and remodel to accommodate the increased demand for triglyceride storage. Based on a comprehensive analysis of the total adipose tissue secretome, this article focuses on three areas of adipokine biology: (1) How does the adipocyte interact with the extracellular matrix over the course of obestiy? (2) Does the adipocyte, per se, play a role in the innate immune response? (3) How is the angiogenic profile of adipose tissue linked to the development of insulin resistance? The authors present a comprehensive overview of all of the currently available secreted adipose tissue products that have been identified at the protein level.

引用

页码：753 / +

页数：18

共 74 条

[21] Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARγ [J].

do Nascimento, CO ;

Hunter, L ;

Trayhurn, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 313 (03) :702-708

[22] Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter [J].

Flieger, O ;

Engling, A ;

Bucala, R ;

Lue, HQ ;

Nickel, W ;

Bernhagen, J .

FEBS LETTERS, 2003, 551 (1-3) :78-86

[23] beta 3-adrenergic receptors on white and brown adipocytes mediate beta 3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake - A study using transgenic and gene knockout mice [J].

Grujic, D ;

Susulic, VS ;

Harper, ME ;

HimmsHagen, J ;

Cunningham, BA ;

Corkey, BE ;

Lowell, BB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (28) :17686-17693

[24] Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation [J].

Hosogai, Naomi ;

Fukuhara, Atsunori ;

Oshima, Kazuya ;

Miyata, Yugo ;

Tanaka, Sachiyo ;

Segawa, Katsumori ;

Furukawa, Shigetada ;

Tochino, Yoshihiro ;

Komuro, Ryutaro ;

Matsuda, Morihiro ;

Shimomura, Iichiro .

DIABETES, 2007, 56 (04) :901-911

[25] ADIPOSE EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA - DIRECT ROLE IN OBESITY-LINKED INSULIN RESISTANCE [J].

HOTAMISLIGIL, GS ;

SHARGILL, NS ;

SPIEGELMAN, BM .

SCIENCE, 1993, 259 (5091) :87-91

[26] Obesity-associated improvements in metabolic profile through expansion of adipose tissue [J].

Kim, Ja-Young ;

De Wall, Esther Van ;

Laplante, Mathieu ;

Azzara, Anthony ;

Trujillo, Maria E. ;

Hofmann, Susanna M. ;

Schraw, Todd ;

Durand, Jorge L. ;

Li, Hua ;

Li, Guangyu ;

Jelicks, Linda A. ;

Mehler, Mark F. ;

Hui, David Y. ;

Deshaies, Yves ;

Shulman, Gerald I. ;

Schwartz, Gary J. ;

Scherer, Philipp E. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) :2621-2637

[27] Prevention of fat-induced insulin resistance by salicylate [J].

Kim, JK ;

Kim, YJ ;

Fillmore, JJ ;

Chen, Y ;

Moore, I ;

Lee, JS ;

Yuan, MS ;

Li, ZW ;

Karin, M ;

Perret, P ;

Shoelson, SE ;

Shulman, GI .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (03) :437-446

[28] Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732 [J].

Kim, Yoo Mee ;

An, Juan Ji ;

Jin, Yong-Jun ;

Rhee, Yumie ;

Cha, Bong Soo ;

Lee, Hyun Chul ;

Lim, Sung-Kil .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2007, 38 (3-4) :455-465

[29] Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists [J].

Klimcakova, Eva ;

Moro, Cedric ;

Mazzucotelli, Anne ;

Lolmede, Karine ;

Viguerie, Nathalle ;

Galitzky, Jean ;

Stich, Vladimir ;

Langin, Dominique .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 358 (03) :897-902

[30] Reversal of obesity by targeted ablation of adipose tissue [J].

Kolonin, MG ;

Saha, PK ;

Chan, L ;

Pasqualini, R ;

Arap, W .

NATURE MEDICINE, 2004, 10 (06) :625-632

← 1 2 3 4 5 6 7 8 →