Brain iNOS: current understanding and clinical implications

被引：109

作者：

Licinio, J

Prolo, P

McCann, SM

Wong, ML

机构：

[1] NIMH, Clin Neuroendocrinol Branch, NIH, Bethesda, MD 20892 USA

[2] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 05期

关键词：

D O I：

10.1016/S1357-4310(99)01453-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) is a unique informational substance first identified as the endothelium-derived relaxing factor. It is generated by NO synthases and plays a prominent role in controlling a variety of organ functions in the cardiovascular, immune, reproductive and nervous systems. Inducible nitric oxide synthase (iNOS) is not normally present in the brain in youth but it can be detected in the brain after inflammatory, infectious or ischemic damage, as well as in the normal, aging brain. Brain INOS seems to contribute to the pathophysiology of many diseases that involve the central nervous system, but the role of iNOS appears to go beyond tissue damage. Brain iNOS might be required for adequate repair following injury or damage. The effects of brain iNOS on the balance between damage and repair make this enzyme a promising therapeutic target in human disease.

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页码：225 / 232

页数：8

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