Changing M3G/M6G ratios and pharmacodynamics in a cancer patient during long-term morphine treatment

被引：15

作者：

Andersen, G ^{[1
]}

Christrup, LL

Sjogren, P

Hansen, SH

Jensen, NH

机构：

[1] Herlev Univ Hosp, Ctr Multidisciplinary Pain, DK-2730 Herlev, Denmark

[2] Royal Danish Sch Pharm, DK-2100 Copenhagen, Denmark

[3] Bispebjerg Hosp, Dept Palliat Med, DK-2400 Copenhagen, Denmark

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 2002年 / 23卷 / 02期

关键词：

morphine metabolism; morphine-6-glucuronide; morphine-3-glucuronide; pain; side effects;

D O I：

10.1016/S0885-3924(01)00398-0

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

A cancer patient receiving long-term oral sustained-release morphine treatment and periodically presenting with unusually high plasma M3G/M6G ratios is described. We found the patient's formation of M6G more unstable and perhaps delayed compared to the formation of M6G. There is no apparent explanation for this phenomenon and the high M3G/M6G ratios had no implications for the patients pain experience or side effects from the morphine treatment. (C) US. CancerPain Relief Committee, 2002.

引用

页码：161 / 164

页数：4

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