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Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method

被引：62
作者：
Bishai, WR
Dannenberg, AM
Parrish, N
Ruiz, R
Chen, P
Zook, BC
Johnson, W
Boles, JW
Pitt, MLM
机构：
[1] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Int Hlth, Baltimore, MD USA
[4] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[5] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[6] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[7] George Washington Univ, Med Ctr, Dept Pathol, Washington, DC 20037 USA
[8] George Washington Univ, Med Ctr, Dept Anim Res, Washington, DC 20037 USA
[9] USA, Dept Aerobiol & Prod Evaluat, Med Res Inst Infect Dis, Frederick, MD USA
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 09期
关键词：
D O I：
10.1128/IAI.67.9.4931-4934.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The virulence of the CDC1551 strain of Mycobacterium tuberculosis was compared to that of H37Rv in a rabbit inhalation model. While rabbits that inhaled the two strains produced equal numbers of grossly visible primary tubercles, CDC1551 tubercles were smaller and contained fewer bacilli than H37Rv tubercles. These findings suggest that a miniepidemic near the Kentucky-Tennessee border caused by CDC1551 was due not to increased virulence but to increased transmissibility.
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页码：4931 / 4934
页数：4
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