Genetic approaches to the investigation of rheumatoid arthritis

被引:25
作者
Barton, A
Ollier, W
机构
[1] Univ Manchester, ARCEU, Manchester, Lancs, England
[2] Univ Manchester, Ctr Integrated Genomic Med Res, Manchester, Lancs, England
关键词
D O I
10.1097/00002281-200205000-00012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The investigation of genetic factors affecting the development or severity of rheumatoid arthritis may give new insights into the pathways involved in disease pathogenesis and lead to the identification of novel therapeutic targets. Recently, several novel approaches have been used in the attempt to unravel the complex association of rheumatoid arthritis with the human leukocyte antigen (HLA) gene region. It is clear that non-HLA genes are also involved in disease pathogenesis, and identifying them remains a challenge. In the past year, considerable headway has been made in this field, and some interesting strategies have been used. This review summarizes the results of many of the HLA and non-HLA studies and tries to draw lessons from the investigation of genetic susceptibility factors in other complex diseases. (C) 2002 Lippincott Williams Wilkins, Inc.
引用
收藏
页码:260 / 269
页数:10
相关论文
共 110 条
[51]   Allele-specific quantification of tumor necrosis factor α (TNF) transcription and the role of promoter polymorphisms in rheumatoid arthritis patients and healthy individuals [J].
Kaijzel, EL ;
Bayley, JP ;
van Krugten, MV ;
Smith, L ;
van de Linde, P ;
Bakker, AM ;
Breedveld, FC ;
Huizinga, TWJ ;
Verweij, CL .
GENES AND IMMUNITY, 2001, 2 (03) :135-144
[52]  
Kaltenhäuser S, 2001, J RHEUMATOL, V28, P735
[53]   Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis [J].
Kawasaki, A ;
Tsuchiya, N ;
Fukazawa, T ;
Hashimoto, H ;
Tokunaga, K .
GENES AND IMMUNITY, 2001, 2 (05) :276-279
[54]   Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis [J].
Khani-Hanjani, A ;
Lacaille, D ;
Hoar, D ;
Chalmers, A ;
Horsman, D ;
Anderson, M ;
Balshaw, R ;
Keown, PA .
LANCET, 2000, 356 (9232) :820-825
[55]  
Kilpatrick DC, 1997, BRIT J RHEUMATOL, V36, P207
[56]  
Li JP, 2000, J RHEUMATOL, V27, P2074
[57]  
Macchioni P, 2000, CLIN EXP RHEUMATOL, V18, P553
[58]  
MacGregor AJ, 2000, ARTHRITIS RHEUM, V43, P30, DOI 10.1002/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO
[59]  
2-B
[60]  
MACKAY K, 2001, IN PRESS ARTHRITIS R