Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome

被引：201

作者：

Knezevic, Ana ^{[1
]}

Polasek, Ozren ^{[2
]}

Gornik, Olga ^{[1
]}

Rudan, Igor ^{[3
,4
,5
]}

Campbell, Harry ^{[5
]}

Hayward, Caroline ^{[6
]}

Wright, Alan ^{[6
]}

Kolcic, Ivana ^{[2
]}

O'Donoghue, Niaobh ^{[7
]}

Bones, Jonathan ^{[7
]}

Rudd, Pauline M. ^{[7
]}

Lauc, Gordan ^{[1
,8
]}

机构：

[1] Univ Zagreb, Dept Biochem & Mol Biol, Fac Pharm & Biochem, Zagreb 10000, Croatia

[2] Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Zagreb 10000, Croatia

[3] Univ Split, Sch Med, Croatian Ctr Global Hlth, Split, Croatia

[4] Univ Zagreb, Univ Hosp Sestre Milosrdnice, Inst Clin Med Res, Zagreb, Croatia

[5] Univ Edinburgh, Publ Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland

[6] Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[7] Univ Coll Dublin, Conway Inst, NIBRT, Dublin Oxford Glycobiol Lab, Dublin 4, Ireland

[8] Genos Doo, Osijek 31000, Croatia

来源：

JOURNAL OF PROTEOME RESEARCH | 2009年 / 8卷 / 02期

基金：

英国医学研究理事会;

关键词：

Human plasma glycome; N-glycosylation; Glycan analysis; Variability of glycans; Heritability of glycans; Age-dependent changes; IGG HEAVY-CHAINS; QUANTITATIVE TRAITS; ACUTE-PANCREATITIS; GLYCOSYLATION; GLYCANS; AGE; GLYCOPROTEINS; GLYCOBIOLOGY; FUCOSYLATION; MUTATIONS;

D O I：

10.1021/pr800737u

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma glycans were analyzed in 1008 individuals to evaluate variability and heritability, as well as the main environmental determinants that affect glycan structures. By combining HPLC analysis of fluorescently labeled glycans with sialidase digestion, glycans were separated into 33 chromatographic peaks and quantified. A high level of variability was observed with the median ratio of minimal to maximal values of 6.17 and significant age- and gender-specific differences. Heritability estimates for individual glycans varied widely, ranging from very low to very high. Glycome-wide environmental determinants were also detected with statistically significant effects of different variables including diet, smoking and cholesterol levels.

引用

页码：694 / 701

页数：8

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