Platelet-derived growth factor (PDGF): Actions and mechanisms in vascular smooth muscle

被引：115

作者：

Hughes, AD

Clunn, GF

Refson, J

DemoliouMason, C

机构：

[1] Department of Clinical Pharmacology, St. Mary's Hospital Medical School, Imperial Coll. of Sci. Technol./Med., London W2 1NY, South Wharf Road

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1996年 / 27卷 / 07期

关键词：

platelet-derived growth factor; vascular smooth muscle cells; signal transduction; proliferation; migration; chemotaxis; excitation-contraction coupling; pathophysiology;

D O I：

10.1016/S0306-3623(96)00060-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. PDGF is a highly hydrophilic cationic glycoprotein (Mr 28-35kDa) produced by platelets, monocyte/macrophages, endothelial cells and Vascular smooth muscle cells under some conditions. 2. Since its original description, PDGF has attracted much attention and it is currently believed to play a role in atherosclerosis and other vascular pathologies. 3. This review describes the vascular biology of PDGF. It particularly focuses on recent findings regarding the intracellular signals activated by PDGF in the context of vascular smooth muscle cell proliferation, migration and contraction. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：1079 / 1089

页数：11

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