Warfarin anticoagulation in children: is there a role for a personalized approach to dosing?

被引：4

作者：

Biss, Tina T. ^{[1
]}

Kamali, Farhad ^{[1
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

PHARMACOGENOMICS | 2012年 / 13卷 / 11期

关键词：

anticoagulant; CYP2C9; pediatrics; pharmacogenetics; vitamin K; VKORC1; warfarin; VITAMIN-K ANTAGONISTS; PATIENT CHARACTERISTICS; PEDIATRIC-PATIENTS; DOSE REQUIREMENT; VKORC1; VARIABILITY; CYP2C9; IMPACT; PERFORMANCE; GENOTYPE;

D O I：

10.2217/PGS.12.92

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Studies of children receiving warfarin have shown that body size is the major predictor of warfarin dose. However, polymorphisms in the key genes ... involved in the metabolism and action of warfarin are also responsible for a significant proportion of the interindividual variability in warfarin-dose requirement.

引用

页码：1211 / 1214

页数：4

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