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The Yin-Yang of cobalamin biochemistry

被引：134
作者：
Banerjee, R
机构：
[1] Biochemistry Department, University of Nebraska, Lincoln
来源：
CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 03期
关键词：
D O I：
10.1016/S1074-5521(97)90286-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cobalamins are B-12 cofactors with a reactive cobalt-carbon bond at their core and support the activity of two mammalian enzymes that are both medically important. The reactive organometallic bond of the cofactor can be cleaved either homolytically or heterolytically, but what determines how the enzymes control the fate of this bond?
引用
收藏
页码：175 / 186
页数：12
相关论文
共 90 条
  • [41] Mutations in the B-12-binding region of methionine synthase: How the protein controls methylcobalamin reactivity
    Jarrett, JT
    Amaratunga, M
    Drennan, CL
    Scholten, JD
    Sands, RH
    Ludwig, ML
    Matthews, RG
    [J]. BIOCHEMISTRY, 1996, 35 (07) : 2464 - 2475
  • [42] Protein radical cage slows photolysis of methylcobalamin in methionine synthase from Escherichia coli
    Jarrett, JT
    Drennan, CL
    Amaratunga, M
    Scholten, JD
    Ludwig, ML
    Matthews, RG
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (08) : 1237 - 1246
  • [43] KANG SS, 1992, ANNU REV NUTR, V12, P279, DOI 10.1146/annurev.nu.12.070192.001431
  • [44] THE SYNTHETIC SUBSTRATE SUCCINYL(CARBADETHIA)-COA GENERATES COB(II)ALAMIN ON ADENOSYLCOBALAMIN-DEPENDENT METHYLMALONYL-COA MUTASE
    KEEP, NH
    SMITH, GA
    EVANS, MCW
    DIAKUN, GP
    LEADLAY, PF
    [J]. BIOCHEMICAL JOURNAL, 1993, 295 : 387 - 392
  • [45] KOLHOUSE JF, 1991, J BIOL CHEM, V266, P23010
  • [46] RECOGNITION OF 2 INTRACELLULAR COBALAMIN BINDING-PROTEINS AND THEIR IDENTIFICATION AS METHYLMALONYL-COA MUTASE AND METHIONINE SYNTHETASE
    KOLHOUSE, JF
    ALLEN, RH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (03) : 921 - 925
  • [47] KRAUTLER B, 1994, INORG CHEM, V33, P4128
  • [48] THERMODYNAMIC TRANS-EFFECTS OF THE NUCLEOTIDE BASE IN THE B-12 COENZYMES
    KRAUTLER, B
    [J]. HELVETICA CHIMICA ACTA, 1987, 70 (05) : 1268 - 1278
  • [49] A METHYLNICKEL INTERMEDIATE IN A BIMETALLIC MECHANISM OF ACETYL-COENZYME-A SYNTHESIS BY ANAEROBIC-BACTERIA
    KUMAR, M
    QIU, D
    SPIRO, TG
    RAGSDALE, SW
    [J]. SCIENCE, 1995, 270 (5236) : 628 - 630
  • [50] Human methionine synthase: CDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
    Leclerc, D
    Campeau, E
    Goyette, P
    Adjalla, CE
    Christensen, B
    Ross, M
    Eydoux, P
    Rosenblatt, DS
    Rozen, R
    Gravel, RA
    [J]. HUMAN MOLECULAR GENETICS, 1996, 5 (12) : 1867 - 1874
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