Inflammation in Atherosclerosis

被引：5806

作者：

Libby, Peter ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2012年 / 32卷 / 09期

关键词：

SMOOTH-MUSCLE-CELLS; C-REACTIVE PROTEIN; LEUKOCYTE ADHESION MOLECULE; PROMOTES COLLAGEN ACCUMULATION; INTERLEUKIN-1; GENE-EXPRESSION; ADVANCED HUMAN ATHEROMA; T-CELLS; APOLIPOPROTEIN-E; CORONARY ARTERIOSCLEROSIS; ENDOTHELIAL-CELLS;

D O I：

10.1161/ATVBAHA.108.179705

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers provided a mechanism whereby risk factors for atherosclerosis can alter arterial biology, and produce a systemic milieu that favors atherothrombotic events. The discovery of the immune basis of allograft arteriosclerosis demonstrated that inflammation per se can drive arterial hyperplasia, even in the absence of traditional risk factors. Inflammation regulates aspects of plaque biology that trigger the thrombotic complications of atherosclerosis. Translation of these discoveries to humans has enabled both novel mechanistic insights and practical clinical advances. (Arterioscler Thromb Vasc Biol. 2012;32:2045-2051.)

引用

收藏

页码：2045 / 2051

页数：7

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