Revisiting cell fate specification in the inner ear

被引：207

作者：

Fekete, DM

Wu, DK

机构：

[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

[2] Natl Inst Deafness & Other Commun Disorders, Rockville, MD 20850 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(02)00287-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Generating the diversity of cell types in the inner ear may require an interplay between regional compartmentalization and local cellular interactions. Recent evidence has come from gene targeting, lineage analysis, fate mapping and gene expression studies. Notch signaling and neurogenic gene regulation are involved in patterning or specification of sensory organs, ganglion cells and hair cell mechanoreceptors.

引用

收藏

页码：35 / 42

页数：8

相关论文

共 67 条

[1]

Adam J, 1998, DEVELOPMENT, V125, P4645

[2]

Bae SK, 2000, DEVELOPMENT, V127, P2933

[3] Math1:: An essential gene for the generation of inner ear hair cells [J].

Bermingham, NA ;

Hassan, BA ;

Price, SD ;

Vollrath, MA ;

Ben-Arie, N ;

Eatock, RA ;

Bellen, HJ ;

Lysakowski, A ;

Zoghbi, HY .

SCIENCE, 1999, 284 (5421) :1837-1841

[4] A fate map of chick otic cup closure reveals lineage boundaries in the dorsal otocyst [J].

Brigande, JV ;

Iten, LE ;

Fekete, DM .

DEVELOPMENTAL BIOLOGY, 2000, 227 (02) :256-270

[5] Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role? [J].

Brigande, JV ;

Kiernan, AE ;

Gao, XY ;

Iten, LE ;

Fekete, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :11700-11706

[6] Ectopic Noggin blocks sensory and nonsensory organ morphogenesis in the chicken inner ear [J].

Chang, WS ;

Nunes, FD ;

De Jesus-Escobar, JM ;

Harland, R ;

Wu, DK .

DEVELOPMENTAL BIOLOGY, 1999, 216 (01) :369-381

[7]

Cole LK, 2000, J COMP NEUROL, V424, P509, DOI 10.1002/1096-9861(20000828)424:3<509::AID-CNE8>3.0.CO

[8]

2-Q

[9] Compartment boundaries - at the edge of development [J].

Dahmann, C ;

Basler, K .

TRENDS IN GENETICS, 1999, 15 (08) :320-326

[10] Notch signaling in the development of the inner ear:: Lessons from Drosophila [J].

Eddison, M ;

Le Roux, I ;

Lewis, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :11692-11699

← 1 2 3 4 5 6 7 →