Revisiting cell fate specification in the inner ear

被引：207

作者：

Fekete, DM

Wu, DK

机构：

[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

[2] Natl Inst Deafness & Other Commun Disorders, Rockville, MD 20850 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(02)00287-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Generating the diversity of cell types in the inner ear may require an interplay between regional compartmentalization and local cellular interactions. Recent evidence has come from gene targeting, lineage analysis, fate mapping and gene expression studies. Notch signaling and neurogenic gene regulation are involved in patterning or specification of sensory organs, ganglion cells and hair cell mechanoreceptors.

引用

页码：35 / 42

页数：8

共 67 条

[61] Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia [J].