Spurious hyperkalaemia due to EDTA contamination: common and not always easy to identify

被引：50

作者：

Comes, Michael P. ^{[1
]}

Ford, Clare ^{[1
]}

Gama, Rousseau ^{[1
,2
]}

机构：

[1] New Cross Hosp, Dept Clin Chem, Wolverhampton WV10 0QP, W Midlands, England

[2] Wolverhampton Univ, Res Inst, Wolverhampton WV1 1DJ, W Midlands, England

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 2008年 / 45卷

关键词：

D O I：

10.1258/acb.2008.007241

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: To study the detection and prevalence of spurious hyperkalaemia, due to potassium ethylenediaminetetra-acetic acid (kEDTA) contamination. Methods: In a one-month prospective study, serum EDTA, zinc, calcium, magnesium concentrations and alkaline phosphatase activity were measured in samples with serum potassium >= 6.0 mmol/L. Results: Twenty-eight out of 117 hyperkalaemic samples were contaminated with EDTA. Only serum zinc values below the reference range had 100% sensitivity for indicating EDTA contamination, but even at an optimal specificity of 89% at least 12 potentially genuine hyperkalaemic samples would be rejected. Conclusion: Spurious hyperkalaemia due to kEDTA contamination is common. Gross kEDTA contamination is obvious by marked unexpected hyperkalaemia, hypocalcaemia, hypomagnesaemia and hypozincaemia. Spurious hyperkalaemia due to low concentrations of kEDTA contamination can only be confidently detected by measurement of serum EDTA.

引用

页码：601 / 603

页数：3

共 8 条

[1] EDTA analysis on the Roche MODULAR® analyser [J].

Davidson, D. F. .

ANNALS OF CLINICAL BIOCHEMISTRY, 2007, 44 :294-296

[2] Effects of contamination of blood specimens with liquid potassium-EDTA anticoagulant [J].

Davidson, DF .

ANNALS OF CLINICAL BIOCHEMISTRY, 2002, 39 :273-280

[3] SPURIOUS INCREASE IN PLASMA POTASSIUM CONCENTRATION AND REDUCTION IN PLASMA CALCIUM DUE TO INVITRO CONTAMINATION WITH LIQUID POTASSIUM EDETIC ACID AT PHLEBOTOMY [J].

FITZPATRICK, MF ;

NEWELL, J ;

GRIMES, H ;

EGAN, E .

JOURNAL OF CLINICAL PATHOLOGY, 1987, 40 (05) :588-588

[4]

HADLEY GG, 1955, AM J CLIN PATHOL, V25, P1090

[5] The effect of EDTA contaminated in sera on laboratory data [J].

Imafuku, Y ;

Meguro, S ;

Kanno, K ;

Hiraki, H ;

Nemoto, U ;

Hata, R ;

Takahashi, K ;

Miura, Y ;

Yoshida, H .

CLINICA CHIMICA ACTA, 2002, 325 (1-2) :105-111

[6]

Kolthoff I. M., 1969, QUANTITATIVE CHEM AN, P1150

[7]

KOOPMAN BJ, 1985, CLIN CHEM, V31, P2030

[8] Combined false hyperkalemia and hypocalcemia due to specimen contamination, during routine phlebotomy [J].

Naguib, MT ;

Evans, N .

SOUTHERN MEDICAL JOURNAL, 2002, 95 (10) :1218-1220

← 1 →