学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

被引：187
作者：
Brooksby, Ben
Pogue, Brian W.
Jiang, Shudong
Dehghani, Hamid
Srinivasan, Subhadra
Kogel, Christine
Tosteson, Tor D.
Weaver, John
Poplack, Steven P.
Paulsen, Keith D.
机构：
[1] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA
[2] Dartmouth Med Sch, Dartmouth Hitchcock Med Ctr, Dept Diagnost Radiol, Lebanon, NH 03756 USA
[3] Dartmouth Med Sch, Dartmouth Hitchcock Med Ctr, Dept Community & Family Med, Lebanon, NH 03756 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 23期
关键词：
hemoglobin; magnetic resonance imaging; water; fat; oxygen saturation;
D O I：
10.1073/pnas.0509636103
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 [理学]; 0710 [生物学]; 09 [农学];
摘要：
Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
引用
收藏
页码：8828 / 8833
页数：6
相关论文
共 42 条
[1]
MRI-guided optical tomography: Prospects and computation for a new imaging method [J].
Barbour, RL ;
Graber, HL ;
Chang, JW ;
Barbour, SLS ;
Koo, PC ;
Aronson, R .
IEEE COMPUTATIONAL SCIENCE & ENGINEERING, 1995, 2 (04) :63-77
[2]
Generation of anisotropic-smoothness regularization filters for EIT [J].
Borsic, A ;
Lionheart, WRB ;
McLeod, CN .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2002, 21 (06) :579-587
[3]
Boyd NF, 1998, CANCER EPIDEM BIOMAR, V7, P1133
[4]
Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue:: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure -: art. no. 051504 [J].
Brooksby, B ;
Jiang, SD ;
Dehghani, H ;
Pogue, BW ;
Paulsen, KD ;
Weaver, J ;
Kogel, C ;
Poplack, SP .
JOURNAL OF BIOMEDICAL OPTICS, 2005, 10 (05)
[5]
Spectral priors improve near-infrared diffuse tomography more than spatial priors [J].
Brooksby, B ;
Srinivasan, S ;
Jiang, SD ;
Dehghani, H ;
Pogue, BW ;
Paulsen, KD ;
Weaver, J ;
Kogel, C ;
Poplack, SP .
OPTICS LETTERS, 2005, 30 (15) :1968-1970
[6]
Magnetic resonance-guided near-infrared tomography of the breast [J].
Brooksby, B ;
Jiang, SD ;
Dehghani, H ;
Pogue, BW ;
Paulsen, KD ;
Kogel, C ;
Doyley, M ;
Weaver, JB ;
Poplack, SP .
REVIEW OF SCIENTIFIC INSTRUMENTS, 2004, 75 (12) :5262-5270
[7]
BROOKSBY B, 2006, IN PRESS P SPIE INT
[8]
BROOKSBY B, 2005, THESIS DARTMOUTH COL
[9]
Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI:: Algorithm development for reconstructing heterogeneities [J].
Brooksby, BA ;
Dehghani, H ;
Pogue, BW ;
Paulsen, KD .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2003, 9 (02) :199-209
[10]
Sources of absorption and scattering contrast for near-infrared optical mammography [J].
Cerussi, AE ;
Berger, AJ ;
Bevilacqua, F ;
Shah, N ;
Jakubowski, D ;
Butler, J ;
Holcombe, RF ;
Tromberg, BJ .
ACADEMIC RADIOLOGY, 2001, 8 (03) :211-218
12345