Enantioseparation of chiral vasodilator drug isoxsuprine in high-performance liquid chromatography and capillary electrophoresis

被引：29

作者：

Chankvetadze, B

Burjanadze, N

Blaschke, G

机构：

[1] Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany

[2] Tbilisi State Univ, Sch Chem, Mol Recognit & Separat Sci Lab, GE-380028 Tbilisi, Georgia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 27卷 / 1-2期

关键词：

enantioseparations; chiral HPLC; chiral CE; isoxsuprine; cyclodextrins; polysaccharide derivatives;

D O I：

10.1016/S0731-7085(01)00552-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two independent methods using high-performance liquid chromatography (HPLC) on polysaccharide type chiral stationary phase (CSP) and capillary electrophoresis (CE) with native and derivatised cyclodextrins (CD) have been proposed for the enantioseparation of chiral vasodilator drug isoxsuprine (ISP). The methods have been compared from the viewpoint of separation characteristics (efficiency, sensitivity, analysis time, costs, etc.). (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：153 / 159

页数：7

共 10 条

[1] Separation selectivity in chiral capillary electrophoresis with charged selectors [J].