Separation selectivity in chiral capillary electrophoresis with charged selectors

This review summarizes the separation selectivity in chiral capillary electrophoresis with charged selectors. Different parameters for a description of the separation selectivity, i.e., the absolute and the relative mobility difference between the enantiomers, the ratio of apparent mobilities and the ratio of effective mobilities as well as the intrinsic (recognition) selectivity, are compared. The electrophoretic mobility of the enantiomers and their migration with the electroosmotic flow are discussed from the viewpoint of separation selectivity. The affinity and mobility-related contributions in the separation selectivity with charged chiral selectors are separately considered. The selectivity of the separations using charged chiral selectors as carriers, in systems with a combination of chiral selectors as well as selectivity in chiral capillary electrochromatography are also briefly addressed. (C) 1997 Elsevier Science B.V.