The amyloid-β precursor protein:: integrating structure with biological function

被引：218

作者：

Reinhard, C ^{[1
]}

Hébert, SS ^{[1
]}

De Strooper, B ^{[1
]}

机构：

[1] KU Leuven & VIB, Ctr Human Genet, Dept Human Genet, Lab Neuronal Cell Biol & Gene Transfer, B-3000 Louvain, Belgium

来源：

EMBO JOURNAL | 2005年 / 24卷 / 23期

关键词：

Alzheimer's disease; amyloid-beta precursor protein; APP; structural and functional relationships;

D O I：

10.1038/sj.emboj.7600860

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteolytic processing of the amyloid-beta precursor protein (APP) generates the A beta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.

引用

页码：3996 / 4006

页数：11

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