Male pseudohermaphroditism related to complications at conception, in early pregnancy or in prenatal growth

被引:23
作者
Francois, I [1 ]
van Helvoirt, M [1 ]
de Zegher, F [1 ]
机构
[1] Univ Leuven, Dept Pediat, Louvain, Belgium
关键词
male pseudohermaphroditism; fetus; growth; conception; pregnancy;
D O I
10.1159/000023321
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We examined whether male pseudohermaphroditism, when unexplained, is associated with reduced prenatal growth. Birth weight SD scores of 29 children with male pseudohermaphroditism were compared. The scores of children with an unexplained condition (median -2.1 SD) were found to be lower (p = 0.0001) than those of children with an explained condition (median -0.4 SD). In the majority of cases of unexplained male pseudohermaphroditism, there was a complicated history before conception or in early pregnancy. In conclusion, hitherto unexplained male pseudohermaphroditism was found to be associated with reduced prenatal growth and complications at conception or in early pregnancy.
引用
收藏
页码:91 / 95
页数:5
相关论文
共 24 条
[1]   Etiologic classification of severe hypospadias: Implications for prognosis and management [J].
Albers, N ;
Ulrichs, C ;
Gluer, S ;
Sinnecker, GHG ;
Mildenberger, H ;
Brodehl, J .
JOURNAL OF PEDIATRICS, 1997, 131 (03) :386-392
[2]   MUTATIONS OF THE ANDROGEN RECEPTOR CODING SEQUENCE ARE INFREQUENT IN PATIENTS WITH ISOLATED HYPOSPADIAS [J].
ALLERA, A ;
HERBST, MA ;
GRIFFIN, JE ;
WILSON, JD ;
SCHWEIKERT, HU ;
MCPHAUL, MJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (09) :2697-2699
[3]   DECREASED IMMUNOREACTIVE ANDROGEN RECEPTOR LEVELS ARE NOT THE CAUSE OF ISOLATED HYPOSPADIAS [J].
BENTVELSEN, FM ;
BRINKMANN, AO ;
VANDERLINDEN, JETM ;
SCHRODER, FH ;
NIJMAN, JM .
BRITISH JOURNAL OF UROLOGY, 1995, 76 (03) :384-388
[4]  
BURSTEIN S, 1979, LANCET, V2, P983
[5]   DOES IMMUNOLOGICAL INTERCOURSE PREVENT PREECLAMPSIA [J].
CLARK, DA .
LANCET, 1994, 344 (8928) :969-970
[6]   Androgens and fetal growth [J].
de Zegher, F ;
Francois, I ;
Boehmer, ALM ;
Saggese, G ;
Müller, J ;
Hiort, O ;
Sultan, C ;
Clayton, P ;
Brauner, R ;
Cacciari, E ;
Ibàñez, L ;
Van Vliet, G ;
Tiulpakov, A ;
Saka, N ;
Ritzén, M ;
Sippell, WG .
HORMONE RESEARCH, 1998, 50 (04) :243-244
[7]   Small as fetus and short as child: From endogenous to exogenous growth hormone [J].
deZegher, F ;
Francois, I ;
vanHelvoirt, M ;
VandenBerghe, G .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (07) :2021-2026
[8]  
DEZEGHER F, 1999, GROWTH GENET HORM, V15, P1
[9]   Adrenarche and fetal growth [J].
Francois, I ;
deZegher, F .
PEDIATRIC RESEARCH, 1997, 41 (03) :440-442
[10]   Low birth weight and subsequent male subfertility [J].
Francois, I ;
deZegher, F ;
Spiessens, C ;
DHooghe, T ;
Vanderschueren, D .
PEDIATRIC RESEARCH, 1997, 42 (06) :899-901