New Insights into the Role of the Immune Microenvironment in Breast Carcinoma

被引：55

作者：

de la Cruz-Merino, Luis ^{[1
]}

Barco-Sanchez, Antonio ^{[2
]}

Henao Carrasco, Fernando ^{[1
]}

Nogales Fernandez, Esteban ^{[1
]}

Vallejo Benitez, Ana ^{[3
]}

Brugal Molina, Javier ^{[3
]}

Martinez Peinado, Antonio ^{[2
]}

Grueso Lopez, Ana ^{[1
]}

Ruiz Borrego, Manuel ^{[4
]}

Codes Manuel de Villena, Manuel ^{[1
]}

Sanchez-Margalet, Victor ^{[2
]}

Nieto-Garcia, Adoracion ^{[5
]}

Alba Conejo, Emilio ^{[6
]}

Casares Lagar, Noelia ^{[7
]}

Ibanez Martinez, Jose ^{[3
]}

机构：

[1] Hosp Univ Virgen Macarena, Dept Clin Oncol, Seville 41009, Spain

[2] Hosp Univ Virgen Macarena, Dept Biochem, Seville 41009, Spain

[3] Hosp Univ Virgen Macarena, Dept Pathol, Seville 41009, Spain

[4] Hosp Univ Virgen del Rocio, Dept Clin Oncol, Seville 41013, Spain

[5] Univ Seville, Dept Stat, E-41009 Seville, Spain

[6] Hosp Univ Virgen de la Victoria, Dept Clin Oncol, Malaga 29010, Spain

[7] Univ Navarra, CIMA, Pamplona 31008, Spain

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2013年

关键词：

REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; TRANSCRIPTION FACTOR FOXP3; COLONY-STIMULATING FACTOR; CANCER-PATIENTS; SUPPRESSOR-CELLS; PERIPHERAL-BLOOD; SOLID TUMORS; ANTICANCER CHEMOTHERAPY; ANTI-CTLA-4; ANTIBODIES;

D O I：

10.1155/2013/785317

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future.

引用

页数：11

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