Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

被引：3031

作者：

Biswas, Subhra K. ^{[1
]}

Mantovani, Alberto ^{[2
,3
]}

机构：

[1] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore, Singapore

[2] Inst Ricovero & Cura Carattere, Ist Clin Humanitas, Rozzano, Italy

[3] Univ Milan, Dept Translat Med, I-20122 Milan, Italy

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 10期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; HUMAN DECIDUAL MACROPHAGES; ALTERNATIVE ACTIVATION; DIFFERENTIAL REGULATION; IMMUNE SURVEILLANCE; SUPPRESSOR-CELLS; M2; MACROPHAGES; POOR-PROGNOSIS; KAPPA-B;

D O I：

10.1038/ni.1937

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.

引用

页码：889 / 896

页数：8

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