Familial temporal lobe epilepsy with febrile seizures

被引：41

作者：

Depondt, C

Van Paesschen, W

Matthijs, G

Legius, E

Martens, K

Demaerel, P

Wilms, G

机构：

[1] Univ Hosp, Dept Neuroradiol, Louvain, Belgium

[2] Univ Hosp, Dept Neurol, Louvain, Belgium

[3] Univ Hosp, Ctr Human Genet, Louvain, Belgium

来源：

NEUROLOGY | 2002年 / 58卷 / 09期

关键词：

D O I：

10.1212/WNL.58.9.1429

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Described are the clinical, EEG, MR, and genetic characteristics of 106 members of a family with autosomal dominant temporal lobe epilepsy (TLE) and febrile seizures (FS), with 22 affected individuals. Eleven patients had a history of FS, and 10 patients had TLE. EEG showed epileptic activity in five. None had hippocampal sclerosis. There was no evidence for linkage to 13 candidate loci. This large family with autosomal dominant TLE has a distinct phenotype and shows no linkage to known candidate regions for familial partial epilepsy and FS.

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页码：1429 / 1433

页数：5

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