LOCALIZATION OF A GENE FOR PARTIAL EPILEPSY TO CHROMOSOME 10Q

被引:291
作者
OTTMAN, R
RISCH, N
HAUSER, WA
PEDLEY, TA
LEE, JH
BARKERCUMMINGS, C
LUSTENBERGER, A
NAGLE, KJ
LEE, KS
SCHEUER, ML
NEYSTAT, M
SUSSER, M
WILHELMSEN, KC
机构
[1] COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL,NEW YORK,NY 10032
[2] COLUMBIA UNIV,DEPT NEUROL,NEW YORK,NY 10032
[3] NEW YORK STATE PSYCHIAT INST & HOSP,DEPT EPIDEMIOL BRAIN DISORDERS RES,NEW YORK,NY 10032
[4] STANFORD UNIV,SCH MED,DEPT GENET,STANFORD,CA 94305
关键词
D O I
10.1038/ng0595-56
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta=0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum rod score for this haplotype is 4.83 at theta=0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.
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收藏
页码:56 / 60
页数:5
相关论文
共 25 条
[1]  
[Anonymous], 1981, EPILEPSIA, V22, P489
[2]  
COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252
[3]   LOCALIZATION OF IDIOPATHIC GENERALIZED EPILEPSY ON CHROMOSOME 6P IN FAMILIES OF JUVENILE MYOCLONIC EPILEPSY PATIENTS [J].
DURNER, M ;
SANDER, T ;
GREENBERG, DA ;
JOHNSON, K ;
BECKMANNAGETTA, G ;
JANZ, D .
NEUROLOGY, 1991, 41 (10) :1651-1655
[4]   JUVENILE MYOCLONIC EPILEPSY (JME) MAY BE LINKED TO THE BF AND HLA LOCI ON HUMAN CHROMOSOME-6 [J].
GREENBERG, DA ;
DELGADOESCUETA, AV ;
WIDELITZ, H ;
SPARKES, RS ;
TREIMAN, L ;
MALDONADO, HM ;
PARK, MS ;
TERASAKI, PI .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1988, 31 (01) :185-192
[5]   THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP [J].
GYAPAY, G ;
MORISSETTE, J ;
VIGNAL, A ;
DIB, C ;
FIZAMES, C ;
MILLASSEAU, P ;
MARC, S ;
BERNARDI, G ;
LATHROP, M ;
WEISSENBACH, J .
NATURE GENETICS, 1994, 7 (02) :246-339
[6]   INCIDENCE OF EPILEPSY AND UNPROVOKED SEIZURES IN ROCHESTER, MINNESOTA - 1935-1984 [J].
HAUSER, WA ;
ANNEGERS, JF ;
KURLAND, LT .
EPILEPSIA, 1993, 34 (03) :453-468
[7]  
HAUSER WA, 1991, EPILEPSIA, V31, P429
[8]   BENIGN EPILEPSY OF CHILDHOOD WITH CENTROTEMPORAL EEG FOCI - GENETIC STUDY [J].
HEIJBEL, J ;
BLOM, S ;
RASMUSON, M .
EPILEPSIA, 1975, 16 (02) :285-293
[9]  
LATHROP GM, 1984, AM J HUM GENET, V36, P460
[10]  
LATHROP GM, 1988, AM J HUM GENET, V42, P498