LOCALIZATION OF A GENE FOR PARTIAL EPILEPSY TO CHROMOSOME 10Q

被引：291

作者：

OTTMAN, R

RISCH, N

HAUSER, WA

PEDLEY, TA

LEE, JH

BARKERCUMMINGS, C

LUSTENBERGER, A

NAGLE, KJ

LEE, KS

SCHEUER, ML

NEYSTAT, M

SUSSER, M

WILHELMSEN, KC

机构：

[1] COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL,NEW YORK,NY 10032

[2] COLUMBIA UNIV,DEPT NEUROL,NEW YORK,NY 10032

[3] NEW YORK STATE PSYCHIAT INST & HOSP,DEPT EPIDEMIOL BRAIN DISORDERS RES,NEW YORK,NY 10032

[4] STANFORD UNIV,SCH MED,DEPT GENET,STANFORD,CA 94305

来源：

NATURE GENETICS | 1995年 / 10卷 / 01期

关键词：

D O I：

10.1038/ng0595-56

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta=0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum rod score for this haplotype is 4.83 at theta=0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.

引用

页码：56 / 60

页数：5

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[21] HYPERVARIABILITY OF SIMPLE SEQUENCES AS A GENERAL SOURCE FOR POLYMORPHIC DNA MARKERS [J].