Enantioselective Mannich-type reaction catalyzed by a chiral Bronsted acid

被引：1411

作者：

Akiyama, T ^{[1
]}

Itoh, J ^{[1
]}

Yokota, K ^{[1
]}

Fuchibe, K ^{[1
]}

机构：

[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 12期

关键词：

asymmetric synthesis; Bronsted acids; enantioselectivity; organocatalysis; Schiff bases;

D O I：

10.1002/anie.200353240

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

No metal required: The Mannich-type reaction of ketene silyl acetals 2 with aldimines 1 proceeded highly enantioselectively to afford the syn isomer of β-aminoesters 3 with up to 96% ee under the influence of a chiral Brønsted acid 4 derived from (R)-BINOL.

引用

页码：1566 / 1568

页数：3

共 64 条

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