Synthesis of quinone and xanthone analogs of rhein

被引：22

作者：

Fonteneau, N

Martin, P

Mondon, M

Ficheux, H

Gesson, JP

机构：

[1] Univ Poitiers, Lab Chim 12, F-86022 Poitiers, France

[2] Fac Sci Poitiers, CNRS UMR 6514, F-86022 Poitiers, France

[3] Lab Negma, F-78771 Magny Les Hameaux, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 44期

关键词：

rhein; xanthone analogs; anthraquinones;

D O I：

10.1016/S0040-4020(01)00918-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy based on carbonylation of aryl triflates has been developed to prepare 7-methyl rhein from emodin and new xanthone analogs of rhein. This approach avoids the oxidation step of methyl derivatives with toxic chromium salts. Although possessing the same structural arrangement of phenol and carboxylic acid functions as found in rhein, these new xanthone derivatives have no activity against IL-1. Thus, the quinone moiety of rhein appears to be essential for activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：9131 / 9135

页数：5

共 34 条

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