Toward an etiological classification of developmental disorders of the kidney and upper urinary tract

被引：66

作者：

Pohl, M

Bhatnagar, V

Mendoza, SA

Nigam, SK

机构：

[1] Univ Calif San Diego, Dept Pediat, Div Nephrol & Hypertens, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA

来源：

KIDNEY INTERNATIONAL | 2002年 / 61卷 / 01期

关键词：

morphology; pathogenetic mechanism; nephrogenesis; human congenital syndromes; kidney malformation; renal pelvis; ureteric bud;

D O I：

10.1046/j.1523-1755.2002.00086.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

There are a large number of developmental disorders and syndromes that affect the kidney and upper urinary tract. These have generally been classified according to morphological criteria established decades ago. Although these classifications have been useful, they are incomplete, including some developmental disorders while excluding others. Here, basic cellular and molecular biology studies of kidney and upper urinary tract development in both rodents and humans are utilized to suggest the basis of a new etiologic, if still tentative, classification scheme. This classification may help to identify candidate genes for human diseases by correlating morphology with pathogenetic mechanisms.

引用

页码：10 / 19

页数：10

共 101 条

[41] A role for Timeless in epithelial morphogenesis during kidney development [J].