Regulation of mammalian cell differentiation by long non-coding RNAs

被引：281

作者：

Hu, Wenqian ^{[1
]}

Alvarez-Dominguez, Juan R. ^{[1
,2
]}

Lodish, Harvey F. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

[3] MIT, Dept Bioengn, Cambridge, MA 02142 USA

来源：

EMBO REPORTS | 2012年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

IncRNA; cell differentiation; pluripotency; X-CHROMOSOME INACTIVATION; EMBRYONIC STEM-CELLS; GENOME-WIDE ANALYSIS; PERVASIVE TRANSCRIPTION; ANTISENSE RNA; IN-VIVO; MUSCLE DIFFERENTIATION; GENE-EXPRESSION; XIST GENE; MOUSE;

D O I：

10.1038/embor.2012.145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at several levels, both during development and during somatic tissue homeostasis. Many long non-coding RNAs have been recognized as an additional layer of regulation in the specification of cellular identities; these non-coding species can modulate gene-expression programmes in various biological contexts through diverse mechanisms at the transcriptional, translational or messenger RNA stability levels. Here, we summarize findings that implicate long non-coding RNAs in the control of mammalian cell differentiation. We focus on several representative differentiation systems and discuss how specific long non-coding-RNAs contribute to the regulation of mammalian development.

引用

页码：971 / 983

页数：13

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