Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material

被引：299

作者：

Holt, RG ^{[1
]}

Roy, RA ^{[1
]}

机构：

[1] Boston Univ, Dept Aerosp & Mech Engn, Boston, MA 02215 USA

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2001年 / 27卷 / 10期

关键词：

acoustic; ultrasound; hyperthermia; cavitation; enhanced heating; bioeffects; bubble; ultrasound contrast agents;

D O I：

10.1016/S0301-5629(01)00438-0

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Time-resolved measurements of the temperature field in an agar-based tissue-mimicking phantom insonated with a large aperture 1-MHz focused acoustic transducer are reported. The acoustic pressure amplitude and insonation duration were varied. Above a critical threshold acoustic pressure, a large increase in the temperature rise during insonation was observed. Evidence for the hypothesis that cavitation bubble activity in the focal zone is the cause of enhanced heating is presented and discussed. Mechanisms for bubble-assisted heating are presented and modeled, and quantitative estimates for the thermal power generated by viscous dissipation and bubble acoustic radiation are given. (C) 2001 World Federation for Ultrasound in Medicine & Biology.

引用

页码：1399 / 1412

页数：14

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