Folded Structures in Protonated Reduced Dipeptides

被引：9

作者：

Grand, Vincent ^{[1
,2
]}

Aubry, Andre

Dupont, Virginie ^{[1
,2
]}

Vicherat, Andre ^{[1
,2
]}

Marraud, Michel ^{[1
,2
]}

机构：

[1] ENSIC, INPL, Lab Macromol Phys Chem, F-54001 Nancy, France

[2] Univ Nancy 1, Lab Cristallog & Modelling Mineral & Biol Mat, Vandoeuvre Les Nancy, France

来源：

JOURNAL OF PEPTIDE SCIENCE | 1996年 / 2卷 / 06期

关键词：

conformational analysis; crystal structure; folded structures; pseudopeptides; reduced peptides;

D O I：

10.1002/psc.78

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reduced dipeptides with the general formula RCO-Xaa-rXbb-N+HR'R '' (rXbb, reduced analogue of residue Xbb: NH-(CHR1)-H-alpha-CrH2) are shown to adopt a folded conformation in solution and in the solid state. The protonated reduced amide bond is an active proton donor capable of interacting with a peptide carbonyl to give a strong hydrogen bond topologically equivalent to the i + 2 or i + 3 -> i interaction. The resulting conformation is similar to the gamma- or beta-turn structure found in peptides and proteins.

引用

页码：381 / 391

页数：11

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