Flavonoid-drug interactions: Effects of flavonoids on ABC transporters

被引：215

作者：

Morris, ME ^{[1
]}

Zhang, SZ ^{[1
]}

机构：

[1] SUNY Buffalo, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Amherst, NY 14260 USA

来源：

LIFE SCIENCES | 2006年 / 78卷 / 18期

关键词：

ABC proteins; p-glycoprotein; MRP; BCRP; breast cancer resistance protein; flavonoids; herbal dietary supplements;

D O I：

10.1016/j.lfs.2005.12.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Flavonoids are present in fruits, vegetables and beverages derived from plants (tea, red wine), and in many dietary supplements or herbal remedies including Ginkgo Biloba, Soy Isoflavones, and Milk Thistle. Flavonoids have been described as health-promoting, disease-preventing dietary supplements, and a high intake of flavonoids has been associated with a reduced risk of cancer, cardiovascular diseases, osteoporosis and other age-related degenerative diseases. Due to an increased public interest in alternative medicine and disease prevention, the use of herbal preparations containing high doses of flavonoids for health maintenance has become very popular, raising the potential for interactions with conventional drug therapies. This review will summarize the current literature regarding the interactions of flavonoids with ATP-binding cassette (ABC) efflux transporters, mainly P-glycoprotein, MRP1, MRP2 and BCRP and discuss the potential consequences for flavonoid-drug transport interactions. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：2116 / 2130

页数：15

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